Drug trials yield higher weight loss

The search for a drug-based solution to the problem of obesity faces a common difficulty – if the treatment is safe it is not effective, and if it is effective it is not safe.

Now, a US trial of a new two-drug combination may have the answer. Low doses of both phentermine and topiramate achieved more than double the weight loss of orlistat, the only drug approved for the long-term treatment of obesity.